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Search Results for " sp ii "

Targets Recommended: Apoptosis Ferroptosis Trk receptor JNK Aurora Kinase Autophagy

6

抑制剂 & 化合物

2

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3109	SP600125 1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone	Apoptosis; Ferroptosis; Trk receptor; JNK; Aurora Kinase; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK; Tyrosine Kinase/Adaptors
	SP600125 (JNK Inhibitor II) 是一种 JNK 抑制剂，抑制 JNK1、JNK2 和 JNK3 (IC50=40/40/90 nM)，具有口服有效性、可逆性和 ATP 竞争性。SP600125 是一种有效的铁死亡抑制剂,可以抑制自噬，诱导凋亡。
T38260	SP 600125, negative control JNK Inhibitor II, negative control
	SP 600125, negative control 是 SP 600125 的甲基化类似物，可用作SP 600125的阴性对照，对 DTP3和GADD45β/MKK7（生长停滞和 DNA 损伤诱导型 β/介原活化蛋白激酶激酶 7）具有抑制作用，能够恢复活化。SP 600125, negative control 对 JNK2 和 JNK3 的 IC50s 分别为 18 和 24 μM。
T21697	Sp-Cyclic AMPS (sodium salt)
	Sp-cAMPS sodium salt 作为 cAMP 类似物，是一种依赖 cAMP 的PKA I 和PKA II 的有效激活剂。Sp-cAMPS sodium salt 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 μM。Sp-cAMPS sodium salt 结合PDE10 GAF 结构域，EC50为 40 μM 。
T38302	Chrysomycin B
	Chrysomycin B 是分离自链霉菌的一种抗生素。Chrysomycin B 能引起人肺腺癌 A549 细胞系的 DNA 损伤，并抑制拓扑异构酶 II。
T73708	Sp-cAMPS triethylamine
	Sp-cAMPS triethylamine，一种 cAMP 类似物，是一种依赖 cAMP 的PKAI 和PKAII 的有效激活剂。Sp-cAMPS triethylamine 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 µM。Sp-cAMPS triethylamine 以EC50为 40 μM 来结合PDE10GAF 域。
T38694	Sp-8-CPT-cAMPS
	Sp-8-CPT-cAMPS is a powerful and specific cAMP analog that activates cAMP-dependent protein kinase A (PKA I and PKA II) selectively and effectively. It exhibits a 153-fold preference for site A of RI over site A of RII, and a 59-fold preference for site B of RII over site B of RI.

化合物

Cat.No: T3109

Synonym: 1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone

Target: Apoptosis, Ferroptosis, Trk receptor, JNK, Aurora Kinase, Autophagy

SP 600125, negative control

Cat.No: T38260

Synonym: JNK Inhibitor II, negative control

Sp-Cyclic AMPS (sodium salt)

Cat.No: T21697

Cat.No: T38302

Sp-cAMPS triethylamine

Cat.No: T73708

Cat.No: T38694

Cat. No.	Product Name	Target	Signaling Pathways
T15636	K-252a Antibiotic K 252a,Antibiotic SF 2370,SF2370	Others	Others
	K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively).
T28379	PF-1163B PF1163B,(-)-PF1163B,PF 1163B
	PF-1163B is an antifungal agent form Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis with IC50 value of 34 ng/ml. PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotox

天然产物

Cat.No: T15636

Synonym: Antibiotic K 252a,Antibiotic SF 2370,SF2370

Target: Others

Cat.No: T28379

Synonym: PF1163B,(-)-PF1163B,PF 1163B

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00498	BSPII Protein, Cynomolgus, Recombinant (His) SP II,IBSP,SPII...	Cynomolgus	HEK293 Cells
	BSPII Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 34.63 kDa and the accession number is A0A2K5UM27.
TMPK-00848	BSPII Protein, Human, Recombinant (His) SP-II,BSP,SP II...	Human	HEK293 Cells
	BSPII Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 34.3 kDa and the accession number is P21815.
TMPK-01028	BSPII Protein, Mouse, Recombinant (His) IBSP,SP II,BSP,BSP	Mouse	HEK293 Cells
	Osteopontin (OPN), bone sialoprotein (BSPII), and osteonectin (ON) belong to a family of glycoproteins, which have been linked to cancer metastasis and progression. Here, we report on the selection of antisense oligonucleotides (ASOs), which are effective in reducing their protein levels.
TMPJ-00445	IBSP Protein, Mouse, Recombinant (His) BNSP,IBSP,Integrin binding sialoprotein,Ce...	Mouse	HEK293 Cells
	Bone sialoprotein 2(IBSP) is a monomeric non‑collagenous member of the SIBLING family of extracellular matrix proteins. It is principally associated with the early stages of bone mineralization. Mouse IBSP is synthesized as a 324 amino acid (aa) precursor that contains a 16 aa signal sequence and a 308 aa mature region. The mature segment is divided into a basic N‑terminus (aa 17 ‑ 62), a central region (aa 63 ‑ 233), and an acidic C‑terminus (aa 234 ‑ 317). IBSP is highly glycosylated, sulfate...
TMPY-06810	SFTPB Protein, Human, Recombinant (His) SFTP3,SMDP1,PSP-B,SFTB3,SP-B	Human	CHO Cells
	Pulmonary surfactant-associated protein B, also known as SFTPB and SP-B, contains one saposin A-type domain and three saposin B-type domains. SP-B is produced primarily by alveolar type II cells (AEC2) but also by nonciliated respiratory epithelial cells lining distal portions of the respiratory tract. Its secretion promotes alveolar homeostasis, stabilizing lipid layers and lowering surface tension at the air-liquid interface in the peripheral air spaces. Alveolar SP-B influences surfactant for...

重组蛋白

BSPII Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00498

Species: Cynomolgus

Expression System: HEK293 Cells

BSPII Protein, Human, Recombinant (His)

Cat.No: TMPK-00848

Species: Human

Expression System: HEK293 Cells

BSPII Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01028

Species: Mouse

Expression System: HEK293 Cells

IBSP Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00445

Species: Mouse

Expression System: HEK293 Cells

SFTPB Protein, Human, Recombinant (His)

Cat.No: TMPY-06810

Species: Human

Expression System: CHO Cells

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